8,518 research outputs found
Grounding, mental causation, and overdetermination
Recently, Kroedel and Schulz have argued that the exclusion problem—which states that certain forms of non-reductive physicalism about the mental are committed to systematic and objectionable causal overdetermination—can be solved by appealing to grounding. Specifically, they defend a principle that links the causal relations of grounded mental events to those of grounding physical events, arguing that this renders mental–physical causal overdetermination unproblematic. Here, we contest Kroedel and Schulz’s result. We argue that their causal-grounding principle is undermotivated, if not outright false. In particular, we contend that the principle has plausible counterexamples, resulting from the fact that some mental states are not fully grounded by goings on ‘in our heads’ but also require external factors to be included in their full grounds. We draw the sceptical conclusion that it remains unclear whether non-reductive physicalists can plausibly respond to the exclusion argument by appealing to considerations of grounding
Treatment of psoriasis with biologic agents in Malta
Introduction: Biologic therapy has
revolutionalised the treatment of moderate to severe
psoriasis leading to improved clinical outcomes and
quality of life scores. This study aims to determine
current biologic use in psoriatic patients at our
Dermatology department at Sir Paul Boffa hospital,
Malta.
Method: All patients who were administered
biologic therapy for psoriasis in Malta until the end
of 2014 were included. Data included demographic
details, disease duration and severity, biologic use
and duration, previously attempted treatments, side
effects, early and late response to biologic using
Psoriasis Area Severity Index (PASI) scores and
Dermatology Life Quality index (DLQI) scores.
Results: A total of 36 patients were started on a
biologic between 2009 and 2014 for psoriasis
(M:25, F:11) with a mean age of 46.9 years. These
included etanercept (n=22), infliximab (n=8),
adalimumab (n=4) and ustekinumab (n=2).
Secondary failure was the main reason why
biologics were stopped and switched. Most patients
had an improvement in their PASI scores after 2 to
4 weeks of starting the biologic and had a PASI 90
score improvement. All patients had more than a 5
point improvement in DLQI score.
Discussion: Biologic use in our department is
on the increase. Our patients had considerable
improvements in their PASI and DLQI scores.
Secondary failures have occurred usually after 2 to
4 years and switching has yielded positive results.
Biologics are expensive drugs and recently we have
switched to cheaper biosimilars. Doctors should be
aware of the treatment options available for
psoriasis patients, their possible side effects and
when to refer to our department. In most cases a
satisfactory response can be achieved.peer-reviewe
Density Matrix Renormalization Group in the Heisenberg Picture
In some cases the state of a quantum system with a large number of subsystems
can be approximated efficiently by the density matrix renormalization group,
which makes use of redundancies in the description of the state. Here we show
that the achievable efficiency can be much better when performing density
matrix renormalization group calculations in the Heisenberg picture, as only
the observable of interest but not the entire state is considered. In some
non-trivial cases, this approach can even be exact for finite bond dimensions.Comment: version to appear in PRL, acronyms in title and abstract expanded,
new improved numerical example
Striped spin liquid crystal ground state instability of kagome antiferromagnets
The Dirac spin liquid ground state of the spin 1/2 Heisenberg kagome
antiferromagnet has potential instabilities[1-4]. This has been suggested as
the reason why it is not strongly supported in large-scale numerical
calculations[5]. However, previous attempts to observe these instabilities have
failed. We report on the discovery of a projected BCS state with lower energy
than the projected Dirac spin liquid state which provides new insight into the
stability of the ground state of the kagome antiferromagnet. The new state has
three remarkable features. First, it breaks both spatial symmetry in an unusual
way that may leave spinons deconfined along one direction. Second, it breaks
the U(1) gauge symmetry down to . Third, it has the spatial symmetry of a
previously proposed "monopole" suggesting that it is an instability of the
Dirac spin liquid. The state described herein also shares a remarkable
similarity to the distortion of the kagome lattice observed at low Zn
concentrations in Zn-Paratacamite suggesting it may already be realized in
these materials.Comment: 4+ pages, 3 figure
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